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. 2019 Jul 29;10(8):570. doi: 10.1038/s41419-019-1778-8

Fig. 7. Overexpression of Cep131 is closely associated with colon cancer progression.

Fig. 7

a HCT116 cells stably expressing vector or untagged Cep131-WT or 2A were infected with shGL2 (control) or shCep131 to eliminate endogenous Cep131 and transplanted into nude mice. After 5 weeks, tumors had grown to maximum sizes and were removed. N/A, not available. Quantification of transplanted tumor volumes (b), measured weekly, and weight (c). Error bars represent means ± SD (N = 6 for each group). *P < 0.05, unpaired Student’s t test. d Tumors were stained with hematoxylin (violet) and eosin (pink) to indicate the nucleus and cytoplasm, respectively. Scale bar, 100 μm. e Immunohistochemistry analysis of centrosome amplification (γTub) and Cep131 expression. Scale bar, 10μm. Quantification of Cep131 overexpression (f) and centrosome amplification (g) in tumor tissues. Error bars represent means ± SD from four tissue sections (N = 2 for each group). *P < 0.05, unpaired Student’s t test