| Therapy Prior to Transplant |
|
|
|
|
|
|
| HMA/IMID (reference) |
1.00 |
|
|
1.00 |
|
|
| Cytoreductive induction type therapy |
0.233 |
0.055–0.994 |
0.049* |
0.311 |
0.072–1.341 |
0.117 |
| Cytoreductive and prior HMA/IMID |
0.811 |
0.281–2.343 |
0.699 |
0.824 |
0.244–2.789 |
0.756 |
| Other prior care/Supportive care |
1.053 |
0.315–3.513 |
0.933 |
0.840 |
0.195–3.615 |
0.815 |
| Disease Diagnosis |
|
|
|
|
|
|
| MDS (reference) |
1.00 |
|
|
1.00 |
|
|
| MPN/MDS overlap or MPN |
2.971 |
1.028–8.586 |
0.044* |
0.492 |
0.114–2.122 |
0.341 |
| AML |
0.724 |
0.306–1.712 |
0.462 |
0.674 |
0.267–1.703 |
0.404 |
| Disease Remission Status at Transplant |
|
|
|
|
|
|
| CR (reference) |
1.00 |
|
|
1.00 |
|
|
| Response less than CR |
1.261 |
0.518–3.072 |
0.609 |
0.884 |
0.346–2.259 |
0.797 |
| Non-responsive/Progressive disease |
1.753 |
0.689–4.461 |
0.239 |
1.042 |
0.377–2.880 |
0.937 |
| Disease Cytogenetics at Diagnosis |
|
|
|
|
|
|
| Non-Monosomal/Non-Complex (reference) |
1.00 |
|
|
1.00 |
|
|
| Monosomal or Complex |
2.846 |
1.301–6.227 |
0.00884* |
3.075 |
1.316–7.182 |
0.009* |
| HCT-CI Score |
|
|
|
|
|
|
| Score 0 (reference) |
1.00 |
|
|
1.00 |
|
|
| Score of 1 or 2 |
1.101 |
0.493–2.461 |
0.815 |
2.249 |
0.883–5.728 |
0.089 |
| Score of 3+
|
1.082 |
0.461–2.539 |
0.857 |
2.024 |
0.757–5.414 |
0.160 |
| Donor:Recipient Gender Mismatch |
|
|
|
|
|
|
| No Mismatch (F:F or M:M) (reference) |
1.00 |
|
|
1.00 |
|
|
| Yes Mismatch (F:M or M:F) |
0.953 |
0.475–1.911 |
0.892 |
0.822 |
0.373–1.811 |
0.627 |
| Age |
|
|
|
|
|
|
| 1 year older |
1.015 |
0.964–1.07 |
0.567 |
1.02 |
0.951–1.094 |
0.582 |
| Disease Type |
|
|
|
|
|
|
| Secondary or Therapy related (reference) |
1.00 |
|
|
1.00 |
|
|
| De Novo |
0.915 |
0.454–1.842 |
0.803 |
1.145 |
0.524–2.501 |
0.734 |
