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. 2019 Jul 29;9:10986. doi: 10.1038/s41598-019-47360-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ingenuity Pathway Analysis of differentially expressed nuclear proteins. The molecular functions and pathways were generated through the use of IPA¹⁵ (QIAGEN Inc., https://www.qiagenbioinformatics.com/products/ingenuity-pathway-analysis). Top five significant Canonical pathways (A) and Molecular and cellular functions (B) identified from analysis of non-redundant list of differentially expressed nuclear proteins (n = 244) from all grades combined and differentially expressed nuclear proteins grade-wise (Grade II- 162, Grade III-131 and Grade IV- 147 proteins).