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. 2019 Jul 29;9:11001. doi: 10.1038/s41598-019-47311-4

Table 2.

Neural network prediction error summary

Network # skin temp inputs Reference rhythm Prediction method n Prediction Error (minutes) Prediction Error Absolute Values (minutes) Correlation with measured phase Percentage predicted within range
Mean Median SD Range Mean Absolute Median Absolute SD Absolute Min Max RMSE r p  ± 15 mins  ± 30 mins  ± 60 mins  ± 120 mins
Trained networks
Fixed sleep 11 Melatonin cross validation 15 5.67 17.82 50.36 166.03 42.49 39.43 25.24 14.21 84.91 48.98 0.43 0.12 6.67 40.00 73.33 100.00
Fixed sleep 1 Melatonin cross validation 15 1.33 11.48 53.00 194.61 40.86 27.01 31.97 7.06 106.29 51.23 0.41 0.15 26.67 53.33 66.67 100.00
Fixed + habitual sleep 11 aMT6s cross validation 26 1.88 −1.46 66.46 256.29 48.71 37.76 44.19 0.81 151.32 65.20 0.46 0.07 26.92 42.31 65.38 92.31
Fixed + habitual sleep 1 aMT6s cross validation 27 −0.91 −4.16 66.83 277.90 50.85 40.98 42.22 2.74 152.60 65.59 0.45 0.03 22.22 37.04 66.67 88.89
Diurnal sleep 1 aMT6s cross validation 56 −0.95 −3.27 92.36 604.60 62.84 48.60 67.16 0.42 312.66 91.54 0.42 0.01 19.64 41.07 66.07 87.50
SWday 1 aMT6s cross validation 29 9.36 −9.21 104.08 541.49 65.68 38.28 80.34 3.34 327.79 102.69 0.39 0.16 17.24 41.38 68.97 86.21
SWnights 1 aMT6s cross validation 19 −22.11 −10.24 212.86 1013.81 143.29 115.28 155.42 1.50 605.48 208.36 0.04 0.84 21.05 31.58 42.11 52.63
Predictions using final networks
SWday 1 aMT6s Fixed + habitual sleep 29 −2.85 −0.41 145.69 884.74 81.87 50.11 119.55 0.41 561.90 143.18 0.46 0.08 24.14 37.93 68.97 82.76
SWnight 1 aMT6s Fixed + habitual sleep 19 314.26 375.79 355.86 1245.97 437.37 403.83 170.18 198.53 695.89 467.69 0.23 0.36 0.00 0.00 0.00 0.00
SWnight 1 aMT6s Diurnal sleep 19 317.70 358.75 337.00 1284.05 422.58 396.71 177.79 196.85 701.92 456.64 0.31 0.22 0.00 0.00 0.00 0.00
Comparative estimation methods
Diurnal sleep - aMT6s mid-sleep 29 −29.45 −43.44 104.19 790.70 73.20 79.27 60.75 0.50 542.90 107.38 0.25 0.17 14.29 26.79 50.00 91.07
SWnight - aMT6s mid-sleep 19 413.13 436.30 185.67 853.40 427.17 436.30 148.38 133.40 720.00 450.92 0.34 0.09 0.00 0.00 0.00 0.00
Diurnal sleep - aMT6s normal range estimate 29 11.05 3.31 150.15 807.18 115.15 100.43 95.76 1.40 542.90 174.66 −0.04 0.75 8.93 14.29 33.93 57.14
SWnight - aMT6s normal range estimate 19 −55.73 −52.96 206.87 854.11 150.01 96.40 149.40 4.42 545.78 208.92 0.12 0.57 5.26 5.26 26.32 63.16
Diurnal sleep - aMT6s random re-sampling 29 0.00 0.00 130.92 900.00 95.71 88.39 87.50 0.00 469.00 129.75 0.10 0.43 8.93 19.64 30.36 64.29
SWnight - aMT6s random re-sampling 19 0.00 11.00 235.99 1012.00 180.11 146.46 148.00 11.00 547.00 229.70 0.33 0.10 5.26 10.53 21.05 36.84

Note: all results are from networks using inputs of blue light irradiance combined with skin temperature. See Supplementary Table S3 for results using alternate input combinations. aMT6s = urinary 6-sulphatoxymelatonin, RMSE = root mean square error. Correlation coefficients were calculated using circular statistics.