Table 4.
Sensitivity analysis of results of risk of having a small-for-gestational-age neonate, corrected for misclassification of exposure, Little Rock, Arkansas, 2015–2017 (N=120 from Table 2, N=23 exposed to ENDS, and N=97 self-reported as unexposed)
Biomarker criteria versus self-report (type of users) | Source of estimates of sensitivity and specificity (n*) | Sensitivity of exposure | Specificity of exposure | Any ENDS current use risk ratio** ( 95% CI) |
---|---|---|---|---|
Self-report | This study | Naïve | Naïve | 2.3 (0.9–5.6) |
Hair nicotine ≥2.77 ng/mL (smokers/ENDS vs unexposed) | This study (76) | 0.83 | 0.85 | 6.5 (2.5–15.0) |
Hair nicotine ≥2.77 ng/mL (smokers vs passive non-smokers) | Kim (289) | 0.84 | 0.82 | 8.5 (3.3–19.5) |
Excludes secondhand exposure to smoke or aerosols from others for the reference category to estimate sensitivity and specificity.
The sensitivity and specificity of the outcome (SGA) measurement is assumed to be perfect (i.e. 1.0).