Fig. 10.

Anti-MPO T-cell responses in other S. aureus pSJH101 6PGD_391–410 immunized mouse strains. a BALB/c (I-A^d/I-E^d expressing, n = 6) and b HLA-DR15 transgenic (Tg, n = 4) mice were immunized with MPO_409–428 (positive control) and pSJH101 6PGD_391–410, then T-cell responses measured ex vivo to either OVA_323–339 (negative control), MPO_409–428, 6PGD_391–410, and recombinant mouse MPO using [³H]-thymidine proliferation assays (top row), and ELISOPT for IFN-γ (middle row) or IL-17A (bottom row). Each dot represents the response from an individual mouse, error bars represents the mean ± s.e.m. Data are representative of two independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001 by Kruskal–Wallis test. Source data are provided as a Source Data file