. Author manuscript; available in PMC: 2020 Jun 5.

Published in final edited form as: Hum Hered. 2019 Jun 5;83(6):315–332. doi: 10.1159/000499711

Table 2.

Simulation scenarios defined by effect size differences between exposure groups and the cutoff for determining physical activity (PA) status.

Simulation scenario	Interaction effect direction	Effect sizes		True cutoff for defining PA status	Measurement error

		β_active	β_inactive

LQ_SYN	Synergistic	0.4	0.8	Lower quartile	Absent
35%_SYN	Synergistic	0.4	0.8	35^th percentile	Absent
MED_SYN	Synergistic	0.4	0.8	Median	Absent
MED_SYN+MEASUREMENT_ERROR	Synergistic	0.5	1.0	Median	Present
LQ_ANT	Antagonistic	−0.58	0.58	Lower quartile	Absent
35%_ANT	Antagonistic	−0.58	0.58	35^th percentile	Absent
MED_ANT	Antagonistic	−0.58	0.58	Median	Absent
MED_ANT+MEASUREMENT_ERROR	Antagonistic	−1.4	1.4	Median	Present

Abbreviations: LQ, lower quartile; MED, median; 35%, 35^th percentile; SYN, synergistic (same effects direction); ANT, antagonistic (opposite effects direction); MEASUREMENT_ERROR, measurement error in Quantitative.