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Free energy of αKL1, αKL2, or both binding to targetsa
| Receptor | Ligand | ΔGbinding (kcal/mol) |
|---|---|---|
| αKL1 | FGF23 | −29.1 ± 3.3 |
| αKL1 | FGFR1c | 0 ± 0 |
| αKL1 | α2-3-sialyllactose | −24.5 ± 3.8 |
| αKL2 | FGF23 | −70.5 ± 4.0 |
| αKL2 | FGFR1c | −63.5 ± 1.8 |
| sKlotho (αKL1 + αKL2) | FGF23 + FGFR1c | −163.1 ± 3.0 |
Free energy of αKL2, αKL1, or both binding to FGF23, FGFR1c, both, or α2-3-sialyllactose calculated from the MD simulations, as described in the Materials and Methods section.
