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. 2019 Jul 29;14(7):e0220474. doi: 10.1371/journal.pone.0220474

Fig 4. The survival time of metastasis-bearing mice treated with cytotoxic drugs was compared to untreated animals.

Fig 4

The animals were treated at days 3, 4 and 5. The dual-ligand nanoparticle formulation was administered at 7.5 mg/kg DOX. In addition to the nanoparticle formulation, treatments included free DOX injected at 7.5 or 2.5 mg/kg (n = 6–8 mice per treatment). The difference between the survival curves of the dual-ligand NP and EGFR-NP-treated groups was assessed by the log-rank (Mantel-Cox) test.