Table 1.
1 | Children ≤18 years of age were the main focus or were clearly reported on separately if part of an adult study. |
2 | Interventions aimed to prevent or treat anxiety disorders. |
a. For prevention, at enrolment/pretest, <50% had a primary anxiety disorder diagnosis. | |
b. For treatment, at enrolment/pretest, ≥50% had a primary anxiety disorder diagnosis. | |
3 | Clear descriptions were provided of participant characteristics, study settings and interventions. |
4 | Participants (or clusters) were randomly assigned to intervention and either control (no-intervention) or comparison (minimal intervention) groups at study outset. |
5 | Outcome measures pertained to anxiety, for example, scales had established reliability and validity or ≥50% of items addressed anxiety symptoms. |
6 | Anxiety indicators included either 1 diagnostic measure where the diagnostician was blinded or 2 symptom measures evaluated by 2 or more informant sources, for example, child, parent or teacher, at least one of whom was blinded. |
7 | Maximum attrition was 20% at post-test (medication studies) or at follow-up (prevention or psychosocial treatment studies) or authors used intention-to-treat analyses. |
8 | For prevention and psychosocial treatment studies, postintervention follow-up was 3 months or more. |
9 | For medication studies, double-blinding and placebo controls were used, and side effects were comprehensively assessed. |
10 | Statistical significance (using p<0.05) was reported for relevant outcome measures at post-test (medication studies) or at follow-up (prevention and psychosocial treatment studies). |
11 | Interventions were evaluated in high-income countries (by World Bank standards). |
12 | Studies focused on populations and settings with applicability to most children who may be at risk of or who may have anxiety, rather than specialised subpopulations. |
*For inclusion, all criteria had to be met.