Table 4.
Post-hoc t-tests of ALFF value analysis for TRD, non-TRD from HCs
| RSN | ROI area | MD | SE | p-value | 95% CI |
|---|---|---|---|---|---|
| HC vs TRD | |||||
| Sensory/somatomotor hand | 19 | −0.207 | 0.062 | 0.002* | −0.33 to −0.08 |
| Default mode (PCC) | 89 | 0.254 | 0.123 | 0.040* | 0.006 to 0.50 |
| HC vs non-TRD | |||||
| Sensory/somatomotor hand | 24 | −0.152 | 0.059 | 0.013* | −0.27 to −0.03 |
| Auditory (insula) | 61 | −0.050 | 0.018 | 0.009* | −0.09 to −0.01 |
| Default mode (PCC) | 89 | 0.378 | 0.117 | 0.002* | 0.14 to 0.61 |
| Fronto-parietal task control | 177 | 0.178 | 0.069 | 0.014* | 0.04 to 0.32 |
| Fronto-parietal task control | 179 | −0.198 | 0.076 | 0.017* | −0.34 to 0.04 |
| Fronto-parietal task control | 196 | 0.156 | 0.059 | 0.012* | 0.04 to 0.28 |
| Subcortical | 234 | −0.063 | 0.022 | 0.007* | −0.11 to −0.02 |
| TRD vs non-TRD | |||||
| Sensory/somatomotor hand | 19 | 0.177 | 0.63 | 0.007* | 0.05 to 0.30 |
| Auditory (temporal) | 62 | 0.252 | 0.097 | 0.012* | 0.06 to 0.45 |
| Default mode (LDLPFC) | 99 | 0.162 | 0.054 | 0.004* | 0.05 to 0.27 |
Note: Post-hoc t-tests with least-significant difference (LSD), *p<0.05.
Abbreviations: RSN, resting state network; ROI, regions of interests; MD, mean difference; SE, standard error; TRD, treatment-resistant depression; HCs, healthy controls; non-TRD, non-treatment-resistant depression; PCC, posterior cingulate cortex; LDLPFC, left dorsolateral prefrontal cortex; ALFF, amplitude of low-frequency fluctuations.