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The schematic diagram illustrates the nuclear factor of activated T cells 1 (NFAT1)-MDM2 pathway in breast cancer. In the cytoplasm, calcineurin dephosphorylates NFAT1 and induces its nuclear translocation. NFAT1 can also be rephosphorylated by various kinases. In the nucleus, the dephosphorylated NFAT1 interacts with multiple transcriptional partners to activate the transcription of MDM2. MDM2 targets itself for ubiquitination and degradation.
