Table 2.
CNV regions identified to be associated with the platinum-resistant phenotype, as identified by DPtest using the SNP array and WES data, with an FDR controlled at 0.2. If a region is identified by both SNP array and WES data, we mark the region with bold font. Locations are from human genome build 37. The genes are those that have been reported in the literature as being associated with ovarian cancer or cancer drug resistance in or near the interval.
| Chrom | Start | End | Selected Gene & Literature |
|---|---|---|---|
| 1 | 18,029, 434 | 21,576, 796 | 1p36 Alvarez et al., 2001 |
| 1 | 244,183, 432 | 249,222,471 | AKT3 TCGA, 2011 |
| 4 | 96,324,052 | 99, 069, 827 | 4q23 TCGA, 2011 |
| 6 | 155,184, 273 | 171,050, 993 | RPS6KA2 Bignone et al., 2007 |
| 10 | 124,671, 655 | 129,282, 460 | HTRA1 Chien et al., 2004 |
| 10 | 133, 326, 776 | 135,424,083 | |
| 15 | 42, 373, 631 | 49,408, 050 | 15q21 TCGA, 2011 |
| 15 | 55,311,786 | 56,928, 535 | CCPG1 Bosquet et al., 2016 |
| 15 | 87,201,931 | 93,590,130 | RCCD1 Kar et al., 2016 |
| 15 | 99,797,210 | 102,429,113 | IGF1R Denduluria et al., 2015 |