Table 2.

Differentially Regulated Proteins Identified by TMT-MS in Sera of Girls with High Urine Concentrations of BPA

Protein IDa	Protein Nameb	Group prob-ability	No. unique peptides	Fold change (Rx/C)c	SAMd
P10323	acrosin	0.99	4	+2.80	1.48
O75969	A-kinase anchor	0.94	2	+2.52	2.38
Q01484	ankyrin-2	0.99	4	+2.21	1.69
P46013	antigen Ki-67	0.95	4	+3.65	1.41
Q9P203	BTB/POZ domain-containing 7	0.94	3	+2.52	2.09
Q9UPV0	centrosomal protein of 164	0.98	2	+3.04	1.84
B7ZML1	chromodomain helicase DNA binding protein	0.82	4	+3.06	1.68
Q5I2W7	cytochrome P450, family 24, A1	0.72	2	−2.57	1.16
Q8TDD1	DEAD (Asp-Glu-Ala-Asp) box polypeptide 54	0.87	4	−2.17	1.09
Q5T1A1	DC-stamp domain-containing 2	0.93	3	+2.33	1.07
Q96QB1	deleted in liver cancer 1 (DLCI)	0.83	3	−2.95	1.24
Q9NZW4	dentin sialophosphoprotein	0.99	4	−2.20	1.00
Q9UBC3	DNA (cytosine-5)-methyltransferase 3B (DNMT3B)	0.93	2	−2.51	1.77
P11532	dystrophin	0.92	4	+3.I8	0.99
B4E391	elongation factor Ts	0.98	2	−4.37	1.37
Q9UPY3	endoribonuclease dicer	0.80	2	+2.00	1.56
O60841	eukaryotic translation initiation factor 5B	0.99	4	+2.19	I.00
Q9NV70	exocyst complex component	0.95	3	+2.02	2.32
Q149M6	exophilin 5	1.00	4	+2.79	1.72
Q81YW5	E3 ubiquitin- ligase	0.96	2	+2.45	1.00
O14964	hepatocyte growth factor-regulated tyrosine kinase substrate	0.90	2	+2.48	0.87
Q7Z2Y8	interferon-induced very large GTPase I	0.83	2	+4.50	0.89
A6PVS8	leucine-rich repeat and IQ domain-containing 3	0.89	2	+2.33	0.84
Q8NEZ4	lysine-specific methyltransferase 2C	0.99	6	+2.44	0.8I
O14686	lysine-specific methyltransferase 2D	0.94	3	+2.02	1.62
Q8N6Q8	methyltransferase-like protein 25	0.9I	4	−2.52	1.48
O60307	microtubule-associated serine/thr- kinase 3	0.84	3	+3.48	1.24
P45985	mitogen-activated kinase kinase 4 (MKK4)	0.95	2	+3.08	1.12
Q7Z4B4	MSTP159	0.97	2	+6.14	0.97
P12882	myosin-1 a,b	0.99	5	−2.13	0.80
Q9UKX2	myosin-2 a,,b	0.91	2	−2.13	0.80
Q9Y411–3	myosin-va	0.98	5	+3.13	1.11
P14543	nidogen _1	0.98	2	+2.3I	0.8I
P49790	nucleoporin 153	0.74	3	−2.08	1.66
Q81VF1	NUT family member 2A	0.97	3	−3.44	1.62
A6NNL0	NUT family member 2B	0.98	3	+3.29	0.91
Q9HC10	otoferlin	0.84	2	+2.30	2.79
Q92576	PHD finger 3	0.79	2	−4.13	1.38
B7Z9C9	potassium large conductance ca-activated channel, M beta 3	0.96	2	+2.13	0.97
Q6NUQ1	RAD50-interacting 1	0.92	2	−2.68	1.05
P49247	ribose-5-phosphate isomerase	0.94	2	−3.61	0.88
Q92730	rho family GTPase 1	0.94	2	−3.61	0.88
Q9Y4G6	talin-2	0.90	4	+2.54	1.43
Q16881	thioredoxin reductase 1	0.92	3	+2.19	1.21
Q00WD0	THO complex subunit 4	0.80	3	−2.06	2.15
Q12931	TNF receptor-associated protein 1	0.81	2	+2.51	1.01
Q9Y2W1	thyroid hormone receptor-associated protein 3	0.90	4	+4.30	4.04
Q9UL62	transient receptor potential channel 5 (TRPC5)	0.93	3	+2.40	1.23
PI7948	vascular endothelial growth factor receptor 1	1.00	4	−2.21	0.87
Q64LD2	WD repeat-containing 25	0.99	2	+2.25	0.86
O15231	zinc finger 185	0.92	2	+2.72	0.98

^aProteins identified using the Human Genome DB ID.

^bProteins in bold are carcinogenesis-related proteins.

^CPositive and negative fold change in protein expression indicate up- and down-regulation of protein expression relative to control, respectively.

^dSignificance analysis of microarray (SAM); cut off |±0.8| calculated as described in Materials and Methods.