Table 5.

Differentially Regulated Proteins Identified by TMT-MS in Sera of Girls with High Urine Concentrations of MBzP

Protein IDa	Protein nameb	Group prob ability	No. unique peptides	Fold change (Rx/C)c	SAMd
Q9UJX4	anaphase-promoting complex subunit 5	0.87	2	−2.26	1.26
P02649	apolipo E	0.99	2	+2.16	0.82
Q9UBJ2	ATP-binding cassette sub-family D member 2	0.86	2	−3.45	3.18
Q5X5Y0	ATP synthase subunit a	0.96	2	+2.25	1.09
Q9NP11	bromodomain-containing 7	1.00	3	+2.47	0.90
O14578	citron Rho-interacting kinase	0.99	5	+2.95	1.41
P35663	cylicin-1	0.99	4	+2.16	1.02
Q9HCK1	DBF4-type zinc finger-containing 2	1.00	5	−2.34	1.10
060231	DEAH (Asp-Glu-Ala-His) box polypeptide 16	0.88	3	+4.94	1.53
Q99543	DnaJ homolog subfamily C member 2	0.99	2	+2.57	0.92
O60673	DNA polymerase zeta catalytic subunit	0.92	2	−2.66	0.95
Q8WXX0	dynein heavy chain 7	0.80	2	+2.11	2.33
O75411	Krueppel-like factor 10 (KLFI0)	0.95	2	+2.61	1.47
P08F94	fibrocystin	0.98	2	−2.16	1.07
Q5TBA9	furry homolog	0.96	5	+2.51	1.02
A6NFK2	glutaredoxin domain-containing cysteine-rich 2	0.99	2	−2.65	0.87
P10144	granzyme B	0.81	3	+3.41	2.18
B4DRD6	histone H1	1.00	4	+2.28	1.22
Q9BYW2	histone-lysine N-methyltransferase	0.99	3	−3.36	1.53
D3DW85	iron-responsive element binding 2	0.94	2	+2.30	1.47
O60738	KB07	0.97	2	+2.58	1.27
B0YJ32	laminin alpha-3 chain 1	1.00	7	+2.73	0.85
O95447	leber congenital amaurosis 5-like	0.88	2	−3.05	1.84
B3KNZ9	megakaryocyte-associated tyrosine-kinase	0.98	2	+2.37	1.33
Q6P444	mitochondrial fission regulator 2	0.98	2	+3.02	1.08
Q9Y3A3	MOB family member 4, phocein	0.99	3	−2.15	2.70
Q9Y5Q3	musculoaponeuroticfibrosarcoma oncogene homolog B	0.90	2	+2.17	1.04
Q9UKN7	myosin-XV	0.88	3	−2.81	1.07
060313	optic atrophy 1	0.75	2	+2.26	1.41
Q9BRX2	pelota homolog	0.75	2	+2.73	2.16
Q9BV10–2	PHD finger protein 20	0.71	2	+2.21	0.95
P78356	phosphatidylinositol-5-phosphate 4-kinase type-2 beta	0.87	2	−2.80	1.34
Q9ULM0	pleckstrin homology domain-containing family H member 1	0.99	2	+2.16	1.02
Q13563	polycystin-2	0.85	2	+3.96	3.05
Q96P66	probable G- coupled receptor 101	0.84	2	+2.14	1.30
Q05BX6	RABEP1	0.91	3	+2.22	1.81
A8K322	RAD54 homolog B (RAD54B)	0.85	3	+2.01	2.72
Q9NS23	ras association domain-containing 1	0.72	2	−3.29	1.11
P06400	retinoblastoma-associated protein (RB1)	0.95	2	+2.30	0.90
P27169	serum paraoxonase/arylesterase 1	1.00	2	+2.61	2.33
B3KWZ6	sperm associated antigen 17	0.96	4	+2.28	1.01
Q5VWG9	transcription initiation factor TFIID subunit 3	0.80	2	+2.24	1.29
A0PJ48	TAOK2	0.97	4	+3.05	0.86
P28289	tropomodulin-1	0.93	2	+2.57	0.93
P04275	von Willebrand factor	0.97	5	+2.31	0.97
O43345	zinc finger 208	0.88	3	+2.29	1.92
P49207	60S ribosomal L34	0.95	2	+2.24	1.31

^aProteins identified using the Human Genome DB ID.

^bProteins in bold are consistent with cancer prevention.

^cPositive and negative fold change in protein expression indicate up- and down-regulation of protein expression relative to control, respectively.

^dSignificance analysis of microarray (SAM); cut off |±0.8| calculated as described in Materials and Methods.