Table 2.

Spearman correlation analysis of CD4+ T_EM and CD8+ T_EM S. Typhi-specific single (S) or multifunctional (MF) responses in LPMC and PBMC obtained from unvaccinated (n=18) and Ty21a-vaccinated (n=12) volunteers.

Net S. Typhi-specific responses	CD4+ vs CD8+ TEM cells (Spearman r)
	Unvaccinated				Ty21a vaccinated
	LPMC		PBMC		LPMC		PBMC
	S	MF	S	MF	S	MF	S	MF
CD107A+	–0.155	0.568	0.046	0.444	0.708	0.451	–0.023	–0.213
IFNγ+	–0.166	0.446	0.560	0.502	0.049	0.665	0.562	0.184
TNFα+	0.223	0.702	0.162	0.108	–0.084	0.784	0.146	–0.608
IL-17A+	–0.021	–0.034	0.179	–0.131	–0.156	0.663	0.516	0.182
IL-2+	0.194	0.101	0.140	–0.139	0.107	0.346	0.381	0.107
MIP1β+	–0.284	0.520	0.129	–0.004	0.606	0.886	–0.160	–0.455
	Orange p<0.0005		Green p<0.005		Red P<0.05