Table 3.

Multivariate regression analysis of S.sonnei LPS-specific serum antibody responses in vaccine groups compared to placebo recipients among Bangladeshi adults.

			LPS-IgA		LPS-IgG
		Placebo (n = 6)	3x105 CFU (n = 10)	3x106 CFU (n = 8)	3x105 CFU (n = 10)	3x106 CFU (n = 8)
Day 7	Unadjusted	Ref.	0.47 (−0.98, 1.92)	0.97 (−0.52, 2.46)	0.21 (−0.32, 0.73)	0.57 (0.10, 1.04)*
	Adjusteda	Ref.	1.15 (−0.13, 2.43)	1.32 (−0.17, 2.80)	0.44 (0.14, 0.73)**	0.73 (0.28, 1.17)**
Day 28	Unadjusted	Ref.	0.16 (−1.37, 1.70)	0.76 (−0.77, 2.29)	0.17 (−0.42, 0.76)	0.46 (−0.06, 1.00)
	Adjusteda	Ref.	0.75 (−0.60, 2.10)	0.99 (−0.40, 2.38)	0.43 (0.11, 0.75)*	0.66 (0.24, 1.08)**
Day 35	Unadjusted	Ref.	0.28 (−1.43, 2.00)	1.13 (−0.43, 2.69)	0.33 (−0.21, 0.87)	0.58 (0.05, 1.11)*
	Adjusteda	Ref.	0.44 (−1.14, 2.02)	0.91 (−0.72, 2.54)	0.44 (0.10, 0.77)*	0.79 (0.29, 1.28)**
Day 56	Unadjusted	Ref.	0.90 (−0.42, 2.22)	1.07 (−0.47, 2.61)	0.21 (−0.30, 0.69)	0.51 (0.004, 1.02)*
	Adjusteda	Ref.	1.16 (−0.15, 2.47)	0.93 (−0.62, 2.49)	0.37 (0.05, 0.69)*	0.62 (0.26, 0.97)**
Day 63	Unadjusted	Ref.	0.79 (−0.63, 2.20)	1.45 (0.21, 2.68)*	0.22 (−0.24, 0.69)	0.56 (0.13, 0.98)*
	Adjusteda	Ref.	1.43 (0.48, 2.39)**	1.34 (0.31, 2.37)*	0.43 (0.06, 0.80)*	0.63 (0.27, 1.00)**
Day 84	Unadjusted	Ref.	0.58 (−0.92, 2.09)	1.09 (−0.36, 2.54)	0.22 (−0.26, 0.70)	0.55 (0.12, 0.98)*
	Adjusteda	Ref.	1.33 (0.30, 2.36)*	1.00 (−0.31, 2.31)	0.34 (−0.01, 0.70)	0.60 (0.35, 0.86)***

Data are given as β-coefficient (Confidence Interval). ^aadjusted by age, sex and pre-existing titers. *p < 0.05, **p < 0.01, ***p < 0.001.