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. 2019 Jul 24;12(7):e227299. doi: 10.1136/bcr-2018-227299

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© BMJ Publishing Group Limited 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

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Resolution of intracranial and leptomeningeal metastases of patient in case 2. MRI scans of (A) and (C) show multiple intracranial and leptomeningeal metastases during brigatinib use, whereas MRI scans of (B) and (D) show regression of the intracranial and leptomeningeal metastases after 1 month therapy with lorlatinib.