Table 2. A 19-year-old female with pseudohyperthyroidism due to self-prescribed 20 mg/day biotin for hair and nail changes in iron deficiency anemia and polycystic ovary syndrome.
Investigations | Initial investigations Aug 30, 2018 | On biotin | Off biotin | Normal values | |||
Nov 22, 2018 | Nov 24, 2018 | 24 hours after | 48 hours after | 72 hours after | |||
TSH µIU/ml | 0.86 | 0.04 | 0.05 | 1.04 | 1.11 | 0.27-4.2 | |
FT4 ng/dl | 1.63 | 3.23 | 3.48 | 2.55 | 2.30 | 1.04 | 0.93-1.7 |
FT3 pg/ml | 4.01 | 2.24 | 1.21-4.18 | ||||
TT4 µg/dl | 14.00 | 22.12 | 20.17 | 10.30 | 5.1-14.1 | ||
TT3 ng/ml | 0.9 | 4.21 | 4.56 | 1.56 | 0.8-2 | ||
Anti-TPO IU/ml | 3.22 | 0-34 | |||||
TRAb mIU/ml | 0.68 | <2 | |||||
¶ Roche Cobas e411 immunoassay. TSH: Thyroid-Stimulating Hormone, FT4: Free Thyroxine, FT3: Free Triiodothyronine, TT4: Total Thyroxine, TT3: Total triiodothyronine, Anti-TPO: Antithyroid Peroxidase, TRAb: Thyrotropin Receptor Antibody. |