Table 2.
HLA compatibility of SLE son–mother pairs compared with healthy son–mother pairs*
| Locus/compatibility | Patients | Controls | OR (95% CI) | P |
|---|---|---|---|---|
| DRB11† | ||||
| Bidirectional | 9 (30) | 6 (8) | 5.0 (1.6–15.7) | 0.006 |
| Mother from son’s perspective | 4 (13) | 11 (14) | 0.9 (0.3–3.1) | 0.88 |
| Son from mother’s perspective | 3 (10) | 9 (12) | 0.8 (0.2–3.3) | 0.79 |
| DRB12‡ | ||||
| Bidirectional | 5 (19) | 5 (7) | 3.2 (0.9–12.2) | 0.08 |
| Mother from son’s perspective | 4 (15) | 7 (9) | 1.7 (0.5–6.4) | 0.42 |
| Son from mother’s perspective | 2 (7) | 4 (5) | 1.4 (0.2–8.3) | 0.68 |
| DQA1 | ||||
| Bidirectional | 11 (38) | 16 (21) | 2.3 (0.9–5.8) | 0.081 |
| Mother from son’s perspective | 4 (14) | 7 (9) | 1.6 (0.4–5.9) | 0.50 |
| Son from mother’s perspective | 3 (10) | 13 (17) | 0.6 (0.1–2.1) | 0.39 |
| DQB1 | ||||
| Bidirectional | 7 (27) | 12 (16) | 2.0 (0.7–5.7) | 0.21 |
| Mother from son’s perspective | 3 (12) | 5 (7) | 1.9 (0.4–8.4) | 0.42 |
| Son from mother’s perspective | 2 (8) | 10 (13) | 0.6 (0.1–2.7) | 0.46 |
*
Values are the number (%) of subjects. The analyses were not adjusted for age or ethnicity. For DRB11, n = 30 patients and 76 controls; for DRB12, n = 27 patients and 75 controls; for DQA1, n = 29 patients and 76 controls; for DQB1, n = 26 patients and 76 controls. See Table 1 for descriptions of compatibility. SLE = systemic lupus erythematosus; OR = odds ratio; 95% CI = 95% confidence interval.
†
Basic DRB1 groups DRB1*01 through DRB1*14 sharing sequence similarities but not necessarily identical throughout the entire DRβl chain.
‡
Specific alleles within DRB1 groups.