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Contrast-enhanced CT performed before (a) and after 2 cycles (b), 4 cycles (c), and 6 cycles (d) of regorafenib therapy: intratumoral air appeared on contrast-enhanced CT after 2 cycles of regorafenib therapy (b) which had not been observed prior to treatment (a), suggestive of tumor necrosis. The size of the intratumoral airspace increased gradually with the continuation of regorafenib therapy with a decreasing size of the tumor (c, d). CT: computed tomography
