Table 1.
Baseline characteristics of participants stratified by GlycA quartiles, Multi-Ethnic Study of Atherosclerosis (2000–2002)*,†.
| Characteristics | Total | GlycA (μmol/L) | p-for-trend across quartiles | |||
|---|---|---|---|---|---|---|
| Q1 (204.7 – 337.0) |
Q2 (338.0–374.9) |
Q3 (375.0 – 418.6) |
Q4 (419.8–787.8) |
|||
| n | 6466 | 1637 | 1599 | 1628 | 1602 | - |
| Age, years | 62.2 (10.3) | 61.4 (10.5) | 62.4 (10.2) | 62.6 (10.2) | 62.2 (10.1) | 0.01 |
| Female | 3426 (53%) | 629 (38.4%) | 754 (47.2%) | 910 (55.9%) | 1133 (70.7%) | <0.001 |
| Race | <0.001 | |||||
| White | 2515 (38.9%) | 605 (37%) | 656 (41%) | 611 (37.5%) | 643 (40.1%) | - |
| Black | 1746 (27%) | 416 (25.4%) | 384 (24%) | 469 (28.8%) | 477 (29.8%) | - |
| Hispanic | 1416 (21.9%) | 292 (17.8%) | 339 (21.2%) | 378 (23.2%) | 407 (25.4%) | - |
| Chinese | 789 (12.2%) | 324 (19.8%) | 220 (13.8%) | 170 (10.4%) | 75 (4.7%) | - |
| Education | <0.001 | |||||
| Less than high school | 1175 (18.2%) | 244 (14.9%) | 280 (17.5%) | 319 (19.6%) | 332 (20.7%) | - |
| High school or vocational school | 2663 (41.2%) | 581 (35.5%) | 631 (39.5%) | 702 (43.1%) | 749 (46.8%) | - |
| College, graduate or professional school | 2628 (40.6%) | 812 (49.6%) | 688 (43%) | 607 (37.3%) | 521 (32.5%) | - |
| BMI, kg/m2 | 28.3 (5.4) | 26.4 (4.7) | 27.6 (4.9) | 28.8 (5.3) | 30.4 (6.0) | <0.001 |
| Current smoker | 816 (12.6%) | 137 (8.4%) | 175 (10.9%) | 223 (13.7%) | 281 (17.5%) | <0.001 |
| Former smoker | 2349 (36.3%) | 630 (38.5%) | 591 (37.0%) | 585 (35.9%) | 543 (33.9%) | <0.001 |
| Pack-years of smoking‡ | 16.5 (6.0 – 33.0) | 13.5 (5.0 – 26.3) | 16.0 (5.6 – 31.5) | 17.0 (6.5 – 34.0) | 19.8 (7.5 – 38.0) | <0.001 |
| Physical activity, MET-minutes/week‡,§ | 4020 (1980 – 7515) | 4268 (2228 – 8190) | 4155 (1995 – 7650) | 4073 (1980 – 7320) | 3638 (1700 – 6893) | <0.001 |
| Systolic blood pressure, mmHg | 126.5 (21.5) | 122.8 (20.8) | 125.7 (21.3) | 128.2 (21.6) | 129.3 (21.9) | <0.001 |
| eGFR, ml/min per 1.73 m2 | 77.7 (16.2) | 79.0 (15.0) | 78.0 (14.8) | 77.1 (16.5) | 76.7 (18.1) | <0.001 |
| Total chol, mg/dL | 194.3 (35.5) | 186.2 (32.1) | 194 (33.7) | 196.5 (34.9) | 200.6 (39.3) | <0.001 |
| HDL-C, mg/dL | 51.0 (14.8) | 52.6 (15.5) | 51.2 (15.1) | 50.3 (14.6) | 50.0 (13.8) | <0.001 |
| Diabetes status | 808 (12.5%) | 136 (8.3%) | 164 (10.3%) | 214 (13.1%) | 294 (18.4%) | <0.001 |
| Antihypertensive | 2390 (37%) | 442 (27%) | 542 (33.9%) | 649 (39.9%) | 757 (47.3%) | <0.001 |
| Lipid-lowering | 1061 (16.4%) | 228 (13.9%) | 227 (14.2%) | 291 (17.9%) | 315 (19.7%) | <0.001 |
| hsCRP, mg/L‡ | 1.90 (0.83 – 4.18) | 0.85 (0.45 – 1.65) | 1.42 (0.74 – 2.79) | 2.41 (1.14 – 4.59) | 4.56 (2.35 – 9.29) | <0.001 |
| IL-6, pg/mL‡ | 1.20 (0.77 – 1.88) | 0.88 (0.59 – 1.4) | 1.06 (0.72 – 1.65) | 1.28 (0.86 – 1.93) | 1.65 (1.15 – 2.54) | <0.001 |
| Fibrinogen, mg/dL‡ | 338 (295 – 388) | 300 (268 – 337) | 327 (291 – 370) | 351 (308 – 395) | 385 (337 – 440) | <0.001 |
*
Abbreviations: BMI =body mass index; Chol =cholesterol; eGFR =estimated glomerular filtration rate; HDL-C = high density lipoprotein cholesterol; hsCRP =high-sensitivity C-reactive protein; IL-6 =interleukin-6; MET =metabolic equivalent of task.
†
Data are presented as mean (standard deviation) for continuous variables and as count (percentages) for categorical variables, unless otherwise specified.
‡
Data presented as median (25th - 75th percentile).
§
Results are for participants with values greater than zero.