Table 4.
Association between fat depots and risk of prostate cancer among 1,832 men in the AGES-Reykjavik Study, 2002-2015: By BMI
| Total prostate cancer | High-grade prostate cancer | Advanced prostate cancer | Fatal prostate cancer | |||||
|---|---|---|---|---|---|---|---|---|
| Events/ Total |
Fully-adjusted HR (95% CI)1 |
Events/ Total |
Fully-adjusted HR (95% CI)1 |
Events/ Total |
Fully-adjusted HR (95% CI)1 |
Events/ Total |
Fully-adjusted HR (95% CI)1 |
|
| Abdominal visceral, per 1 SD (85.7 cm2) increase |
||||||||
| BMI <27 kg/m2 | 99/981 | 1.20 (0.91, 1.57) | 26/981 | 1.31 (0.76, 2.24) | 20/981 | 1.95 (1.07, 3.54) | 15/981 | 2.13 (1.12, 4.05) |
| BMI ≥27 kg/m2 | 73/851 | 1.05 (0.83, 1.34) | 17/851 | 0.97 (0.59, 1.61) | 21/851 | 1.11 (0.73, 1.68) | 16/851 | 0.83 (0.47, 1.48) |
| P-value2 | 0.82 | 0.92 | 0.67 | 0.41 | ||||
| Abdominal subcutaneous, per 1 SD (85.6 cm2) increase |
||||||||
| BMI <27 kg/m2 | 99/981 | 0.97 (0.69, 1.37) | 26/981 | 1.60 (0.82, 3.11) | 20/981 | 1.02 (0.48, 2.16) | 15/981 | 1.34 (0.56, 3.21) |
| BMI ≥27 kg/m2 | 73/851 | 1.12 (0.88, 1.42) | 17/851 | 1.14 (0.70, 1.85) | 21/851 | 1.33 (0.87, 2.04) | 16/851 | 1.27 (0.75, 2.17) |
| P-value2 | 0.51 | 0.67 | 0.31 | 0.72 | ||||
| Thigh intermuscular, per 1 SD (16.0 cm2) increase |
||||||||
| BMI <27 kg/m2 | 99/981 | 0.90 (0.65, 1.22) | 26/981 | 0.86 (0.46, 1.63) | 20/981 | 0.59 (0.28, 1.25) | 15/981 | 0.65 (0.28, 1.52) |
| BMI ≥27 kg/m2 | 73/851 | 0.99 (0.79, 1.24) | 17/851 | 1.11 (0.70, 1.74) | 21/851 | 1.11 (0.73, 1.69) | 16/851 | 1.56 (0.96, 2.53) |
| P-value2 | 0.78 | 0.63 | 0.67 | 0.08 | ||||
| Thigh subcutaneous, per 1 SD (39.2 cm2) increase |
||||||||
| BMI <27 kg/m2 | 99/981 | 1.12 (0.84, 1.51) | 26/981 | 1.66 (0.99, 2.79) | 20/981 | 1.07 (0.55, 2.08) | 15/981 | 1.16 (0.55, 2.44) |
| BMI ≥27 kg/m2 | 73/851 | 1.08 (0.88, 1.33) | 17/851 | 1.19 (0.80, 1.78) | 21/851 | 1.34 (0.95, 1.90) | 16/851 | 1.50 (0.96, 2.33) |
| P-value2 | 0.59 | 0.45 | 0.17 | 0.14 | ||||
HR: Hazard ratio; CI: Confidence interval; BMI: Body mass index.
1
Adjusted for the following variables, measured at study entry: age (continuous), height (continuous), family history of prostate cancer (yes, no), smoking status (never, former, current), education (primary/secondary, college/university), physical activity (≤3 hours/week, ≥4 hours/week), and physician visit over past 12 months (yes, no).
2
Likelihood ratio test for heterogeneity of the HRs from the two strata.