Table 3.
Proportion of women reporting sexual activity at week 12 by intervention arm. Report of sexual activity in the past month was obtained from week 12 visit questionnaires, while report of sexual activity or penetrative sex in the past week was from participant diaries for the week prior to the final study visit.
| Difference |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Vaginal estradiol + placebo gel | Vaginal moisturizer + placebo tablet | Dual placebo | Estradiol vs. Placebo | Moisturizer vs. placebo | ||||||
| Outcome | N | Percent (95% CI) | N | Percent (95% CI) | N | Percent (95% CI) | OR a | p value | OR a | p value |
| Sexual activity in the past month | 99 | 77.8 (69.4, 86.1) | 99 | 86.9 (80.1, 93.6) | 94 | 84.0 (76.5, 91.6) | 0.8 (0.4, 1.7) | 0.52 | 1.5 (0.6, 3.7) | 0.34 |
| Sexual activity in the past week | 93 | 49.5 (39.1, 59.8) | 91 | 35.2 (25.2, 45.2) | 93 | 39.8 (29.7, 49.9) | 1.7 (0.9, 3.1) | 0.10 | 0.8 (0.5, 1.6) | 0.59 |
| Penetrative sex in the past week | 92 | 43.5 (33.2, 53.8) | 91 | 33.0 (23.1, 42.8) | 92 | 34.8 (24.9, 44.7) | 1.6 (0.9, 3.0) | 0.12 | 1.0 (0.5, 1.8) | 0.91 |
a
Odds ratio and p-value from a logistic regression model with week 12 outcome as a function of intervention arm, clinical site, and reported sexual activity in the past month at baseline (yes/no)