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The mRNA expression levels of selected target genes after CYR61 overexpression in dSSc dermal fibroblasts. Data are shown as fold change versus control-transfected cells (mean +/− S.D).
| Gene | Expression fold change vs. control vector after 48 hr transfection (n=10 patients) | p-value |
|---|---|---|
| CYR61 | 213 ± 233 | 0.002 |
| COL1A1 | 0.73 ± 0.12 | 0.002 |
| ACTA2 | 0.75 ± 0.34 | 0.04 |
| PPARG | 1.34 ± 0.49 | 0.01 |
| MMP1 | 3.70 ± 5.32 | 0.002 |
| MMP3 | 2.40 ± 1.62 | 0.004 |
| FGF2 | 1.42 ± 0.53 | 0.01 |
| VEGF | 1.45 ± 0.98 | 0.03 |
