Table 2.
Baseline Vasomotor and Neuropsychological Scores
| Placebo | 50 mg | 100 mg | |
|---|---|---|---|
| (n=24) | (n=23) | (n=24) | |
| Greene Climacteric Scale (GCS) | |||
| Total (0–63) | 13.8 (8.3) | 17.3 (6.3) | 14.8 (8.7) |
| Psychological score (0–33) | 6.8 (4.8) | 9.3 (4.0) | 7.5 (5.2) |
| Anxiety score (0–18) | 3.8 (2.8) | 5.3 (2.7) | 4.5 (2.8) |
| Depression score (0–15) | 3.0 (2.6) | 4.0 (2.1) | 2.9 (2.9) |
| Somatic score (0–21) | 3.0 (3.3) | 3.4 (2.6) | 3.1 (3.5) |
| Vasomotor score (0–9) | 2.8 (1.5) | 3.3 (1.2) | 2.9 (1.5) |
| Sexual score (0–3) | 1.3 (0.9) | 1.3 (0.9) | 1.4 (1.0) |
| Vasomotor composite score components | |||
| Weekly total flushes | 36.2 (39.1) | 28.6 (20.8) | 33.0 (48.9) |
| Greene climacteric flushing items 19 & 20 | 3.0 (1.5) | 3.2 (1.2) | 3.0 (1.4) |
| Vasomotor composite scorea | 0.0 (1.8) | 0.0 (1.2) | −0.2 (1.9) |
| Neuropsychological composite components | |||
| Logical Memory I: immediate recall (0–25) | 14.9 (3.6) | 15.6 (3.0) | 15.6 (3.0) |
| Logical Memory II: delayed recall (0–25) | 13.6 (3.8) | 14.3 (3.1) | 14.1 (2.8) |
| Trail Making: A (150 s maximum) | 125.3 (5.2) | 125.6 (4.3) | 126.0 (6.7) |
| Trail Making: B (300 s maximum) | 246.1 (14.7) | 233.9 (41.1) | 236.2 (29.7) |
| Rey Auditory Verbal Learning: Total words from 5 trials (0–75) | 57.4 (7.1) | 56.5 (7.0) | 57.4 (5.6) |
| Rey Auditory Verbal Learning: Total after long delay (0–15) | 12.3 (2.1) | 11.7 (2.3) | 12.0 (1.7) |
| Continuous Performance Test: omission + commission errors | 10.6 (15.0) | 12.2 (10.1) | 7.2 (7.4) |
| Continuous Performance Test Hit reaction time (s) | 423.0 (82.6) | 431.8 (69.1) | 426.6 (84.0) |
| Verbal fluency, total correct | 44.1 (11.4) | 44.7 (9.4) | 43.6 (7.7) |
| Neuropsychological composite scoreb | 0.70 (5.6) | −1.1 (6.0) | 0.04 (5.8) |
Numbers are mean (SD) or number (%) when indicated
Vasomotor composite = Standardized hot flush (number of weekly hot flushes) plus standardized Greene Climacteric Scale sum of flushing items 19 and 20).
Neuropsychological composite = Sum of standardized scores for: (1) Verbal fluency (total correct), (2) Rey Auditory Verbal Learning: total words from 5 trials, (3) Rey Auditory Verbal Learning Tests: total words after long delay, (4) Continuous Performance Test: number of omission errors + number of commission errors, (5) Continuous Performance Test: Hit reaction time, (6) Trail Making Test: Part A, (7) Trail Making Test: Part B, (8) Logical Memory Test: immediate recall, (9) Logical Memory Test: delayed recall