Table 5.

Mean difference in percent LINE-1 methylation compared to pre-treatment levels

Timepoint	N	Mean difference (CI)	p-value
C1D8
All dose levels	17	−6.23 (−12.23, −0.24)	0.04
DL1	3	−6.67 (−24.84, 11.50)	0.26
DL2	11	−4.82 (−13.06,3.43)	0.22
DL3	3	−11.00 (−49.12, 27.12)	0.34
C1D15	17	−5.76 (−13.31, 1.78)	0.12
C2D1	13	−10.28 (−18.94, −1.63)	0.02
C2D15	10	−9.03 (−19.99, 1.92)	0.10

Mean difference reflects the change in percentage methylation between samples at the indicated timepoints.