Table 4.
KEGG Pathways Enriched With ACR
| Term | Fold enrichment | Genes | p-value | FDR |
|---|---|---|---|---|
| T-cell receptor signaling pathway | 21.5 | CD247, CD3e, CD8a, CD8b, GRAP2, ITK, LCK, CTLA4, IFNG, PDCD1, ZAP70 | 2.70E-11 | 2.90E-10 |
| Natural killer cell–mediated cytotoxicity | 17.2 | CD247, FASLG, LCK, SH2D1A, GZMB, IFNG, KLRK1, PRF1, ZAP70 | 2.40E-08 | 2.60E-07 |
| Primary immunodeficiency | 27.9 | CD3E, CD8A, CD8B, LCK, ZAP70 | 2.40E-05 | 2.60E-04 |
| Cell adhesion molecules | 8.7 | CD8a, CD8b, TIGIT, CTLA4, PDCD1, VCAM1 | 4.90E-04 | 0.0052 |
| Cytokine–cytokine receptor interaction | 6.5 | CXCL13, CXCR3, CXCR6, FASLG, IFNG, IL2RB | 4.90E-04 | 0.0052 |
| Graft-versus-host disease | 24.3 | FASLG, GZMB, IFNG, PRF1 | 5.10E-04 | 0.0055 |
| Allograft rejection | 22.4 | FASLG, GZMB, IFNG, PRF1 | 6.60E-04 | 0.0070 |
ACR, acute cellular rejection; FDR, false discovery rate; KEGG, Kyoto Encyclopedia of Genes and Genomes.