(A) Extracellular volume fraction (ECV) was similar between healthy adults (control; minimum = 0.22, median = 0.26, maximum = 0.28) and diabetic adults (minimum = 0.18, median = 0.25, maximum = 0.30). (B) In parallel, the magnetization transfer ratio (MTR) was statistically similar between healthy (minimum = 89.7%, median = 124.5%, maximum = 147.6%) and diabetic adults (minimum = 105.4%, median = 125.5%, maximum = 147.6%). (C) While native T1-relaxation times were significantly longer among diabetic adults (minimum = 984 ms, median = 1056 ms, maximum = 1098 ms) in comparison to healthy controls (minimum = 983 ms, median = 1013 ms, maximum = 1058 ms), (D) post-contrast T1 times were shorter in diabetics (423 ± 32 ms) vs. healthy controls (449 ± 26 ms).