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. Author manuscript; available in PMC: 2019 Jul 29.
Published in final edited form as: Curr Med Chem. 2019;26(16):2881–2897. doi: 10.2174/0929867324666171116123345

Fig. (2).

Fig. (2).

Processing of G4 by replicative and translesion DNA polymerases. A) A G4 site in template strand stalls the replicative polymerases pol δ and pol ε. B) Pol δ and pol ε are replaced by a translesion polymerase. The translesion polymerase adds a nucleotide opposite the G4 site and synthesis continues without resolving the G4. C) A G4 site in the template strand stalls pol δ and pol ε. Synthesis resumes when PrimPol synthesizes a short dNTP primer downstream of the G-quadruplex.