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. Author manuscript; available in PMC: 2019 Jul 29.

Published in final edited form as: Curr Med Chem. 2019;26(16):2881–2897. doi: 10.2174/0929867324666171116123345

Table 1.

G4-resolving eukaryotic helicases and their proposed biological roles in G4 DNA metabolism.

5’ to 3’ DNA helicases
Helicase	Cellular Function	References
FANCJ	DNA replication	[13, 14, 58–60]
	Epigenetic regulation	[61]
RTEL1	Telomeric G4 resolution	[62, 63]
PIF1	Genomic G4 DNA stability	[15, 64]
	DNA replication	[24, 65]
DNA2	Telomeric G4 resolution	[66]
XPD	G4-regulated gene expression	[67]
3’ to 5’ DNA helicases
Helicase	Cellular Function	References
WRN	Telomeric G4 resolution	[68]
	G4-regulated gene expression	[69–71]
	Epigenetic regulation	[61]
BLM	Telomeric G4 resolution	[72]
	G4-regulated gene expression	[69, 71, 73]
	Epigenetic regulation	[61]
RECQL1^*	G4-regulated gene expression	[74]
XPB^*	G4-regulated gene expression	[67]

^*

DNA helicases shown to bind but not unwind G4 DNA