Table 2.

Genes, localization and function of eukaryotic G4 DNA translesion polymerases.

		Translesion Polymerases Known to Act on G4*
		Rev1	Pol η	Pol κ	pol θ	pol ζ*
Gene encoding catalytic subunit	S. cerevisiae	REV1	RAD30			REV3
	D. melanogaster	rev1	DNApol-η		mus308	mus205/dmREV3
	Mouse	Rev1	Polη	DinB1	Polq	Rev3
	Human	REV1	RAD30AF	DINB1	POLQ	REV3L
	Localization	Nuclear and mitochondrial	Nuclear, potentially mitochondrial	Nuclear	Nuclear	Nuclear and mitochondrial
	Function	Scaffold protein, deoxycytidyl transferase	TLS of helix-distorting lesions	TLS, nucleotide excision repair	DSB repair	TLS, mitochondrial genome maintenance
	References	[91–93]	[94–96]	[88, 97]	[98–100]	[101, 102]

^*Pol ζ is a potential candidate for G4 TLS