Figure 8.
Peroxynitrite supports a metabolic reprogramming in human NF2-associated schwannoma cells. Peroxynitrite supports a metabolic shift in human MD-Schwann cells characterized by decreased oxidative phosphorylation and increased glycolysis and glutamine dependence. Dotted lines indicate mechanisms yet to be elucidated. Ox, oxidized protein; -Tyr-NO2, nitrotyrosine.