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. 2019 Jun 5;294(30):11420–11432. doi: 10.1074/jbc.RA119.007367

Figure 8.

Figure 8.

The structure of porcine STINGCBD in complex with 3′,3′-cGAMP. The black dashed line represents the hydrogen bond formed between ligand and protein. The values indicate the length of hydrogen bond with the unit of Å. The red dashed line represents the repulsive Van der Waals contact (bad contact or bump) and the values show the distance between nonhydrogen-bonding atoms. The waters are shown as red sphere. The ligand is shown as a stick model colored in salmon. The simulated annealing omit Fo − Fc electron-density map for 3′,3′-cGAMP (blue mesh) is contoured at 3 σ. A, overall structure of porcine STINGCBD-3′,3′-cGAMP complex (side view). The red dashed circle shows the disordered lid region in protomer B. B, structural comparison between two protomers in porcine STINGCBD-3′,3′-cGAMP complex. The arrow indicates the tilt of α2-α3 in protomer A relative to it in protomer B. C, detailed interactions between Guanosine moiety of 3′,3′-cGAMP and G site of STING protein. D, detailed interactions between Adenosine moiety of 3′,3′-cGAMP and A site of STING protein.