TABLE 1.
Patient demographics
| Demographic | Values of HIV-positive patients |
Values of HIV-negative patients |
||||
|---|---|---|---|---|---|---|
| TBM culture positive (n = 97) | TBM culture negative (n = 378) | P value | TBM culture positive (n = 8) | TBM culture negative (n = 57) | P value | |
| Median age (yr) (IQR) | 35 (30–41) | 36 (30–43) | 0.36 | 25 (24–27) | 41 (28–55) | 0.006 |
| Sex, male (n [%]) | 64 (66) | 190 (50) | 0.006 | 3 (38) | 27 (47) | 0.88 |
| Median CD4+ T cells/μl (IQR) | 104 (45–167) | 129 (42–346) | 0.06 | 165 (142–264) | 593 (498–842) | 0.003 |
| Prior TB diagnosis (n [%]) | 20 (21) | 163 (43) | <0.0001 | 0 (0) | 5 (9) | 0.38 |
| Median days since HIV diagnosis (IQR) | 14 (3–152) | 270 (30–1825) | <0.0001 | |||
| Taking ART (n [%]) | 33 (34) | 231 (61) | < 0.0001 | |||
| Duration of ART, (median days [IQR]) | 105 (19–723) | 730 (60–1825) | < 0.0001 | |||
| MRCb TBM severity grade (n [%]) | ||||||
| Grade 1 | 13 (13) | 0 (0) | ||||
| Grade 2 | 44 (46) | 3 (37.5) | ||||
| Grade 3 | 32 (33) | 3 (37.5) | ||||
| Unknowna | 8 (8) | 2 (25) | ||||
| Inpatient mortality (n [%]) | 42 (43) | 83 (22) | 0.0002 | 2 (25) | 14 (25) | 0.68 |
| 1-yr morality (n [%]) | 59 (61) | 165 (44) | 0.003 | 2 (25) | 26 (46) | 0.47 |
a
Incomplete neurological examination due to patient’s inability to cooperate or death prior to examination.
b
MRC, Medical Research Council.