TABLE 1.
Antimicrobial | % of isolates with MIC (mg/liter) |
% non-wild type (95% CI) | Clinically resistant (%) | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | 32 | 64 | 128 | 256 | 512 | 1,024 | |||
Ampicillin | 9.1 | 7.8 | 5.2 | 9.1 | 13 | | 35.1 | 14.3 | 5.2 | 1.3 | 0 | 0 | 0 | 0 | 55.8 (44.1–67.2) | 20.8 |
Chloramphenicol* | 0 | 0 | 0 | 0 | 3.9 | 75.3 | 20.8 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0 (0.0–4.7) | 0 |
Daptomycin | 14.3 | 11.7 | 5.2 | 33.8 | 23.4 | | 11.7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 11.7 (5.5–21.0) | |
Erythromycin | 35.1 | 3.9 | 13 | 9.1 | 0 | | 3.9 | 35.1 | 0 | 0 | 0 | 0 | 0 | 0 | 39.0 (28.0–50.8) | 39 |
Gentamicin* | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 100 | 0 | 0 | 0 | 0 | |
Kanamycin* | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 79.2 | 14.3 | 3.9 | 2.6 | 2.6 | |
Lincomycin* | 0 | 0 | 11.7 | 0 | 0 | 2.6 | 85.7 | 0 | 0 | 0 | 0 | 0 | 0 | ||
Linezolid | 0 | 0 | 0 | 55.8 | 42.9 | | 0 | 1.3 | 0 | 0 | 0 | 0 | 0 | 0 | 1.3 (0.0–7.0) | 1.3 |
Penicillin (benzyl) | 27.3 | 11.7 | 7.8 | 7.8 | 31.2 | 3.9 | 5.2 | | 5.2 | 0 | 0 | 0 | 0 | 0 | 5.2 (1.4–12.8) | 10.4 |
Quinupristin-dalfopristin* | 0 | 10.4 | 6.5 | 28.6 | 7.8 | 15.6 | 19.5 | 10.4 | 1.3 | 0 | 0 | 0 | 0 | 54.5 | |
Teicoplanin | 98.7 | 1.3 | 0 | 0 | | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0 (0.0–4.7) | 0 |
Tetracycline | 0 | 0 | 58.4 | 1.3 | 0 | | 0 | 0 | 3.9 | 36.4 | 0 | 0 | 0 | 0 | 40.3 (29.2–52.1) | 40.3 |
Vancomycin | 2.6 | 53.2 | 33.8 | 3.9 | 6.5 | | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0 (0.0–4.7) | 0 |
Virginiamycin | 53.2 | 9.1 | 5.2 | 9.1 | 10.4 | | 10.4 | 1.3 | 1.3 | 0 | 0 | 0 | 0 | 0 | 13.0 (6.4–22.6) |
Note that E. faecium is intrinsically resistant to lincomycin. The percentages of isolates classified as non-wild type with corresponding 95% confidence interval (95% CI) and the percentages classified as clinically resistant are shown. For each drug, vertical bars show the positions of the ECOFF values, and shaded areas indicate the range of dilutions evaluated. ECOFF values are not presently available for antimicrobials denoted by an asterisk (*), and blank boxes in the table indicate a lack of relevant breakpoints.