TABLE 3.
Isolates with an rrl mutation detected by the GenoType NTM-DR assay and/or sequencing
| Species | GenoType NTM-DR assay resultb | erm(41) sequevar | No. of isolates | Sequencing result | Clarithromycin MIC (μg/ml)a |
|---|---|---|---|---|---|
| M. avium | MUT1 (A2058C) | 3 | A2058C | ≥64 | |
| MUT2 (A2058G) | 2 | A2058G | >64 | ||
| 1 | A2058G, A2058T | >64 | |||
| MUT3 (A2059C) | 2 | A2059C | ≥64 | ||
| MUT1 (A2058C), MUT3 (A2059C) | 1 | A2058C, A2058T, A2059C | >64 | ||
| M. intracellulare | MUT1 (A2058C) | 2 | A2058C | >64 | |
| MUT2 (A2058G) | 4 | A2058G | ≥64 | ||
| MUT3 (A2059C) | 1 | A2059C | >64 | ||
| MUT4 (A2059G) | 8 | A2059G | ≥64 | ||
| Other | 1 | A2059T | >64 | ||
| M. abscessus subsp. abscessus | MUT1 (A2058C) | T28 | 4 | A2058C | >64 |
| MUT2 (A2058G) | T28 | 3 | A2058G | ≥64 | |
| C28 | 1 | A2058G | ≥64 | ||
| MUT4 (A2059G) | T28 | 1 | A2059G | 64 | |
| WT | T28 | 1 | A2058T, WT | >64 | |
| M. abscessus subsp. massiliense | MUT1 (A2058C) | T28 | 2 | A2058C | >64 |
| MUT2 (A2058G) | T28 | 5 | A2058G | ≥64 | |
| MUT4 (A2059G) | T28 | 8 | A2059G | ≥64 | |
| T28 | 1 | A2059G | 8 | ||
| Other | T28 | 1 | A2058T | 16 | |
| T28 | 1 | A2057G, A2058G | 32 |
a
All isolates were resistant.
b
Other, wild-type band missing.