TABLE 1.

CLSI-approved broth microdilution MIC QC ranges determined for cefepime and cefepime-enmetazobactam (fixed enmetazobactam concentration of 8 μg/ml) against selected reference strains

Reference strain	Cefepime-enmetazobactam			Cefepime
	MIC QC rangea	No. of doubling dilutions in range	% Of values in rangeb	MIC QC range	No. of doubling dilutions in range	% Of values in range
E. coli ATCC 25922	0.03/8–0.12/8	3	100.0	0.016–0.12c	4	100.0
E. coli ATCC 35218	0.008/8–0.06/8	4	100.0	0.008–0.06	4	100.0
E. coli NCTC 13353	0.03/8–0.12/8d	3	100.0	≥64c		100.0
K. pneumoniae ATCC 700603	0.12/8–0.5/8	3	100.0	0.25–2c	4	100.0
P. aeruginosa ATCC 27853	0.5/8–2/8	3	99.6	0.5–4c	4	100.0

^aQC ranges were approved at the June 2017 meeting of the CLSI Subcommittee on Antimicrobial Susceptibility Testing.

^bPercentage of values in range determined from 240 replicates performed in 8 laboratories.

^cCurrent CLSI QC range (35).

^dExcluding data from one laboratory (statistical outlier).