TABLE 2.

Patient characteristics of three children with heterogenic infection^a

Characteristic	Case 1	Case 2	Case 3
Yr of administration	1984	1986	1992
General characteristic
Age (mo)	32	27	26
Gender	Male	Male	Female
Race	Black	Black	Mixed ancestry
BCG immunization	Unknown	Unknown	Yes
Possible TB household contact	Yes	Unknown	Unknown
TBM stageb
At presentation	IIa	IIa	III
During treatment	IIa	III	IIa
Before death	III	III	III
Outcome	Death	Death	Death
TBM diagnosis	Proven	Probable	Proven
Based on	Histology	Clinical symptoms	Histology
ZN positivity	Yes	No	Yes
Additional disease
Pulmonary TB	Yes	Yes	Yes
Miliary TB	Yes	Unknown	Yes
Organs involved	Thyroid, spleen, hilar lymph nodes	Unknown	Kidney, spleen, liver
Treatment
Tuberculostatics received	Rifampin, isoniazid, pyrazinamide, ethionamide	Rifampin, isoniazid, pyrazinamide, ethionamide, ethambutol	Rifampin, isoniazid, pyrazinamide, ethionamide
Duration until death (days)	17	52	13
Prednisone received	Yes	Yes	No

^aThree children were found to have a heterogenic population of lineages in CNS granulomas. Characteristics of the individual patients are presented in this table.

^bTuberculous meningitis stage at presentation is based on the “refined” British Medical Research Council scale (34).