Table 2.
Bone biomechanics for the L4 vertebral body at the end of the treatment period. Data represent means ± SEM, n = 7–8/group
Sham | OVX | GC-OVX | ABL5 | ABL25 | |
---|---|---|---|---|---|
Ultimate load (N) | 1388 ± 89 | 1256 ± 77 | 894 ± 69 S | 1045 ± 106 | 1095 ± 91 |
Stiffness (N/mm) | 6236 ± 938 | 6910 ± 252 | 4860 ± 336 | 5400 ± 689 | 6309 ± 514 |
Work to ult load (mJ) | 262.4 ± 20.9 | 193.1 ± 21.2 | 131.3 ± 18.3 S | 175.9 ± 26.6 S | 153.4 ± 14.2 S |
SP < 0.05 vs. sham
N newton, mJ millijoule, OVX ovariectomy, GC glucocorticoid, ABL5 abaloparatide 5 μg/kg/day, ABL25 abaloparatide 25 μg/kg/day