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Kinetic parameters of the PAN-1 metallo-β-lactamase.
| Antibiotics | kcat (s−1) | Km (μM) | kcat/Km (mM−1 s−1) |
|---|---|---|---|
| Penicillin G | 23.6 | 161 | 146 |
| Piperacillin | 73.6 | 1074.2 | 68 |
| Cephalothin | 6.9 | 32.2 | 214 |
| Cefoxitin | 1.9 | 13.3 | 143 |
| Ceftazidime | 8.1 | 144.4 | 56 |
| Cefotaxime | 3.9 | 245.7 | 16 |
| Cefepime | <0.01 | >1,000 | ND |
| Aztreonam | <0.01 | >1,000 | ND |
| Imipenem | 43.8 | 470.5 | 93.1 |
| Meropenem | 22.9 | 386 | 59 |
| Ertapenem | 2.9 | 368.5 | 7.8 |
