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. 2019 Jul 23;10:880. doi: 10.3389/fphys.2019.00880

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Copyright © 2019 Charrin, Faes, Sotiaux, Skinner, Pialoux, Joly, Connes and Martin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histopathological analysis of changes in morphology of 11- to 12-week-old AA and SS mice kidneys after 3 weeks of treatment with RAGE antagonist peptide. Representative images with Masson’s trichrome staining (A,B) for determining glomerular area and interstitial fibrosis and Perl’s Blue staining (C) for determining iron deposits (D) representative images of KIM-1 stained kidney sections. Magnification: ×400. Quantification of glomerular area (E), interstitial fibrosis (F), tubular iron deposits (G), and KIM-1 expression (H). Values are means ± SD. NaCl-AA (n = 6; three females and three males), RAP-AA (n = 6; four females and two males), NaCl-SS (n = 7; three females and four males), RAP-SS (n = 7; three females and four males). Scale bar = 50 μm.