Table 1.
Baseline characteristics of patients and healthy volunteers.
| Cohort 1 | Cohort 2 | Cohort 3 | |||||
|---|---|---|---|---|---|---|---|
| Sepsis | Post-OP | Healthy | Sepsis | Post-OP | Healthy | Trauma | |
| n = | 50 | 20 | 20 | 30 | 30 | 30 | 36 |
| Age (years) | 66 (41–88) |
65 (49–80) |
30 (23–44) |
60 (20–84) |
64 (36–85) |
23 (19–45) |
49 (18–85) |
| Male sex | 38 (76) | 10 (50) | 5 (25) | 21 (70) | 23 (77) | 12 (40) | 27 (75) |
| BMI (kg/m2) | 27.2 (18.8–45.9) |
24.9 (29.2–37.2) |
– | 24.8 (18.2–47.8) |
27.4 (16.6–41.2) |
23.0 (18.0–28.4) |
25.4 (19.5–38.6) |
| CLINICAL SCORES | |||||||
| SOFA | 11 (6–18) |
– | – | 14 (6–20) |
– | – | 6 (1–15) |
| ISS | – | – | – | – | – | – | 24 (17–34) |
| SITE OF INFECTION (MULTIPLE NAMING POSSIBLE) | |||||||
| Surgical site | 30 (60) | – | – | 12 (40) | – | – | – |
| Abdominal | 45 (90) | – | – | 11 (36.7) | – | – | – |
| Urinary tract | 1 (2) | – | – | 1 (3.3) | – | – | – |
| Lung | 10 (20) | – | – | 5 (16.7) | – | – | – |
| Other | 1 (2) | – | – | 6 (20) | – | – | – |
| LABORATORY VALUES | |||||||
| Leucocytes (× 103/μl) | 12.1 (1.7–76.0) |
6.9 (4.8–11.2) |
– | 19.2 (1.2–52.6) |
12.2 (4.4–32.8) | 6.6 (4.1–11.4) |
8.9 (4.5–19.2) |
| CRP (mg/l) | 190.7 (19.2–430.3) | 5.5 (2.0–92) |
– | 218.9 (49.6–522.6) | 2.7 (2.0–74.2) |
2 (2.0–5.0) |
16.7 (0.0–161.0) |
| PCT (μg/l) | 8.3 (0.1–288.5) |
– | – | 17.5 (0.3–185.9) |
0.1 (0.05–1.5) | 0.05 (0.05–0.05) | 0.7 (0.05–13) |
| OUTCOME | |||||||
| 28-day-mortality | 11 (22) | 0 (0) | 0 (0) | 12 (40) | 2 (7) | 0 (0) | 1 (3) |
Data are presented either as median (min–max) or as number (percentage) in case of “Male sex” and “28-day-mortality.” BMI, Body mass index; APACHE II, Acute physiology and chronic health evaluation score II; SAPS II, Simplified acute physiology score II; SOFA, Sequential organ failure assessment score; ISS, Injury severity score; Post-OP, postoperative.