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. 2019 Jul 23;10:1620. doi: 10.3389/fimmu.2019.01620

Figure 5.

Figure 5

DIM ameliorates arthritis severity in mice with AIA. (A) The effect of DIM on mean change in body weight of mice after immunization (from day 0 to day 55) monitored every 5 days. (B) The effect of DIM on mean change in knee joint diameter after immunization (from day 0 to day 55) monitored every 5 days. (C) The effect of DIM on the spleen and liver index of mice with AIA and control. Data shown as spleen or liver weight (g)/body weight (g) ×100%. (D) The effect of DIM on IL-6, IL-17, TNF-α, IL-8, and IL-1β expression in serum of mice with AIA and control after immunization on day 40 and 80. (E) The effect of DIM on the pathohistological features of knee joints in mice with AIA. Photomicrographs for knee joint sections stained with H&E (left panel, original magnification 400× ). The scores for inflammatory severity (right panel). All the data were expressed as means ± S.D. n = 6, *P < 0.05, **P < 0.01, ***P < 0.001 vs. Ctrl (normal mice group), #P < 0.05, ##P < 0.01, ###P < 0.001 vs. AIA model group.