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. 2019 Jul 29;39(7):BSR20182200. doi: 10.1042/BSR20182200

Figure 3. BE503655 regulates Wnt/β-catenin pathway in osteosarcoma cells.

Figure 3

(A) RT-PCR analysis was used to determine the mRNA expression of β-catenin in adjacent normal tissues and osteosarcoma tissues. (B) Correlation analysis showed that the expression of β-catenin was positively correlated with BE503655 expression. (C) RT-PCR analysis was used to determine the mRNA expression of β-catenin in MG-63 cells. (D) Western blotting analysis was used to examine the protein expression of β-catenin. (E) The target genes of Wnt/β-catenin pathway (C-myc, cyclin D and MMP-2) were detected by Western blotting analysis. All data were expressed as the mean ± SD (n=3). *P<0.5, **P<0.01, ***P<0.001.