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. 2019 Jul 29;39(7):BSR20182200. doi: 10.1042/BSR20182200

Figure 4. BE503655 knockdown inhibits osteosarcoma cell proliferation, invasion via wnt/β-catenin signaling.

Figure 4

(A) Western blot analysis was used to determine the protein expression of β-catenin, in osteosarcoma cell line. (B) CCK8 assay was used to investigate the role of β-catenin on the effect of BE503655 in the proliferation of MG-63 cells. (C) Flow cytometry results showed that the percent of osteosarcoma cells in S phase inhibited by BE503655 down-regulation was blocked after β-catenin overexpression. (D) Transwell assay was used to determine the role of β-catenin on the effect of BE503655 in the invasion and migeration of MG-63 cells. Scale bar = 100 μm. All data were expressed as the mean ± SD (n=3). Each value of *P<0.05,**P<0.01, ***P<0.001 was deemed to have significant differences.