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. 2019 Jul 23;10:803. doi: 10.3389/fphar.2019.00803

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Copyright © 2019 Reyes-Martinez, Nguyen, Kassan and Gonzalez

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Incubations with recombinant prorenin increase the abundance of COX-2 and NOX-4 via MAPK pathway in M-1 cells. (A). Time response of ERK1/2 phosphorylation after incubations with 10⁻⁸ M human recombinant prorenin (hrPR). MAPK inhibition impairs hrPR-dependent upregulation of COX-2 (B) and NOX-4 (C). *p < 0.05, n = 4.