Table 1.
Physiological parameters in mice after 36 h of subcutaneous infusions with saline, human recombinant prorenin (hrRP), and hrPR plus COX-2 inhibitor NS-398.
| Saline | hrPR | NS398 | hrPR+NS398 | |
|---|---|---|---|---|
| Body weight, g | 22 ± 3 | 20 ± 3 | 18 ± 4 | 19 ± 4 |
| Kidney weight, g | 0.29 ± 0.01 | 0.30 ± 0.02 | 0.28 ± 0.03 | 0.29 ± 0.01 |
| Urine osmolality, mosmol/kgH2O | 345 ± 8 | 375 ± 9* | 348 ± 8 | 380 ± 8* |
| Urine flow, ml/16 h | 6.02 ± 0.02 | 5.35 ± 0.05 | 4.91 ± 0.06 | 4.21 ± 0.10* |
| Estimated GFR, ml·min−1 | 0.92 ± 0.03 | 0.89 ± 0.04 | 0.86 ± 0.05 | 0.84 ± 0.05* |
| FENa % | 0.91 ± 0.02 | 0.88 ± 0.02 | 0.87 ± 0.02 | 0.87 ± 0.03 |
| FEK % | 1.4 ± 0.2 | 1.3 ± 0.3 | 1.4 ± 0.4 | 1.3 ± 0.2 |
*p <0.05 versus Saline group.