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. 2019 Feb 16;9(4):702–710. doi: 10.1016/j.apsb.2019.02.004

Figure 1.

Fig. 1

Ablation of gut microbiota protects from obesity-induced hepatic steatosis and liver injury in hamsters. The hamsters were fed a 60% high-fat diet and given vehicle or antibiotics for 4 weeks (n=5 hamsters/group). (A) The liver weight. (B) The ratio of liver weight to body weight. (C) Representative H&E (upper panel) and oil red O (lower panel) staining of liver sections of the two groups. Scale bars: 200 μm (3 images/hamster). (D) Steatosis degree (the ratio of vacuolar area to whole area in one image, 3 images/hamster). (E) Hepatic triglycerides. (F) Plasma triglycerides. (G) The relative expression of genes involved in fatty acid synthesis, uptake and oxidation in the liver. (H) Plasma ALT levels. (I) Plasma AST levels. Data are presented as the mean±SEM. *P<0.05, **P<0.01 versus vehicle by two-tailed Student׳s t-test.