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. 2019 Feb 14;9(4):734–744. doi: 10.1016/j.apsb.2019.02.003

Figure 5.

Fig. 5

CDN ameliorates LPS-induced septic shock and IL-1β production. (A) Survival of 8-week-old C57BL/6 female mice intraperitoneally injected with LPS (20 mg/kg) in the presence or absence of CDN, MCC950 (50 mg/kg, n=10). Lethality was monitored for 60 h. (B and C) Serum levels of IL-1β (B), TNF-α (C) from C57BL/6 mice pretreated with CDN, MCC950 or vehicle control (n=6) as measured by ELISA 6 h after intraperitoneally LPS (20 mg/kg) injection. Data are shown mean±SEM. Statistics differences were analyzed using an unpaired Student׳s t-test: ***P<0.001 vs. the control. NS, not significant.